Axilum Robotics

Pioneering a new frontier in depression treatment, B1Neuro—led by co-founders Dr Leon Ooi and Dr Ruby Kong —uses functional MRI to guide robotic Transcranial Magnetic Stimulation (TMS), a non-invasive and drug-free alternative for patients unresponsive to medication.   In trials conducted at the Institute of Mental Health (IMH), their personalised method achieved a 70% response rate, compared to 21% with standard TMS.   Supported by NUS Graduate Research Innovation Programme (GRIP) and TTI, B1Neuro is now collaborating with public hospitals to expand access and exploring new uses cases for anxiety, OCD, Alzhemier’s and Parkinson’s.    #NUSEnterprise #NUSGRIP #DeepTech #MentalHealthInnovation #Neurotechnology #PrecisionMedicine #StartupSG

Precision matters in brain stimulation research. That's why we built NaviNIBS from the ground up. Neuronavigation systems use MRI brain scans to guide transcranial magnetic stimulation (TMS) coils to precise anatomical targets — think GPS for the brain, but with millimeter accuracy. Researchers have been stuck between two imperfect options: commercial systems that work well but can't be modified or extended, and open-source alternatives that lack the comprehensive features needed for serious research. Our new paper in Journal of Neural Engineering introduces NaviNIBS (Neuronavigated Noninvasive Brain Stimulation)—a complete open-source neuronavigation platform developed by Chris Cline, co-director of our lab, that bridges this gap. Key advances: 🎯 Enhanced precision: Novel head registration techniques that improve targeting accuracy, especially for multi-session studies where consistency is critical 🤖 Seamless integration: Built-in support for robotic coil positioning and integration with real-time electrophysiology mapping—enabling fully automated motor mapping protocols 🔧 Designed for innovation: Modular addon architecture lets researchers extend functionality without touching core code 📊 Validated performance: Head-to-head testing shows comparable or superior performance vs. commercial systems, with better re-registration precision The real power lies in what this enables: researchers can now develop novel stimulation paradigms, integrate with custom hardware, and share reproducible methods—all while maintaining the precision standards required for rigorous neuroscience. NaviNIBS is freely available and already being used in TMS-EEG studies. We use it every day. The future of brain stimulation research is open source. 📖 Full paper: https://lnkd.in/gCsyJBda 💻 Code & docs: https://lnkd.in/geMbsDCX 🌎 Lab: https://lnkd.in/giAf72Aj X lab link: https://lnkd.in/g2YrKDgZ Stanford University School of Medicine Wu Tsai Neurosciences Institute

What if we could make brain stimulation treatments twice as effective with just music? Most TMS treatments today ignore a critical factor: brain state. We deliver stimulation while patients sit quietly, missing opportunities to optimize when their neural circuits are most receptive to change. That's exactly what Jessica Ross tackled in our lab's latest work, just published as a preprint 🧠🎵 "Sensory Entrained TMS (seTMS) enhances motor cortex plasticity" https://lnkd.in/guvXPaR5 In her previous work (https://lnkd.in/g9G64rKz), Jess had developed sensory entrained TMS (seTMS), where TMS pulses were paired with musical beats to enhance motor excitability. In her next endeavor, Jess has developed sensory entrained iTBS (se-iTBS) - a novel approach that pairs musical rhythms with TMS to synchronize stimulation with the brain's natural excitability cycles. By timing TMS pulses just before musical beats, when sensorimotor rhythms naturally desynchronize and become more excitable, the results were impressive: 👉 se-iTBS more than doubled motor plasticity effects compared to standard protocols (55% vs 26% enhancement) 👉 The enhancement was consistent across 80%+ of participants, regardless of musical background 👉 Effects lasted at least 30 minutes, showing sustained neuroplastic changes 👉 No complex EEG setup required - just strategically timed music This represents a major step toward making brain stimulation more dynamic, brain-state-aware, and effective. The implications for stroke recovery, depression treatment, and other neurological conditions are significant. Instead of fighting the brain's natural rhythms, we're learning to dance with them. The best part? This approach could be implemented in any clinic tomorrow - making precision neuromodulation accessible to patients everywhere. Preprint: https://lnkd.in/guvXPaR5 Lab: https://lnkd.in/g65jxsWQ Patent: https://lnkd.in/gDQSFKhK X: https://lnkd.in/gzhZYQfY Contact us if you are interested in collaborating to build this out and help our patients! 🧠🎵

Magstim Super Rapid2 plus +Brainsight2 +Axilum Cobot Installation in Beijing, China