Emmanuelle Leblanc-Noblesse

Emmanuelle Leblanc-Noblesse

Life Imaging Platform Manager at LVMH Recherche

Location
Orléans Area, France
Industry
Cosmetics

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Emmanuelle Leblanc-Noblesse's Overview

Current
Past
  • Life Imagery Platform Manager at LVMH Recherche
  • PhD at Skin substitute laboratory
Education
  • Université de Lyon
  • Université de Caen
Connections

133 connections

Websites

Emmanuelle Leblanc-Noblesse's Experience

Skin Biology Project manager

Parfums Christian Dior

Privately Held; 5001-10,000 employees; Cosmetics industry

April 2002Present (12 years 6 months)

Life Imagery Platform Manager

LVMH Recherche

Public Company; 10,001+ employees; Luxury Goods & Jewelry industry

20102011 (1 year)

PhD

Skin substitute laboratory

19992002 (3 years)

Emmanuelle Leblanc-Noblesse's Skills & Expertise

  1. Cosmetics
  2. Beauty Industry
  3. Skin Care
  4. Luxury Goods
  5. Personal Care
  6. Product Development
  7. French
  8. Luxury

Emmanuelle Leblanc-Noblesse's Publications

  • Cleavage of Nidogen-1 by Cathepsin S Impairs Its Binding to Basement Membrane Partners

    • PLoS ONE
    • August 28, 2012

    Cathepsin S (catS), which is expressed in normal human keratinocytes and localized close to the dermal-epidermal junction (DEJ) degrades some of major basement membrane (BM) constituents. Among them, catS readily hydrolyzed in a time and dose dependent manner human nidogen-1 (nid-1) and nidogen-2, which are key proteins in the BM structure. CatS preferentially cleaved nid-1 at both acid and neutral pH. Hydrolysis of nid-1 was hampered in murine ctss−/− spleen lysates pretreated with inhibitors of other classes of proteases. Nid-1 was cleaved within its G2 and G3 globular domains that are both involved in interactions with other BM components. Binding assays with soluble and immobilized ligands indicated that catS altered the formation of complexes between nid-1 and other BM components. Assuming that the cleavage of nid-1 impairs its ability to crosslink with BM partners and perturbs the viscoelastic properties of BM matrix, these data indicate that catS may participate in BM proteolysis, in addition to already identified proteases.

Emmanuelle Leblanc-Noblesse's Education

Université de Lyon

Doctor of Philosophy (PhD), Biologie Cellulaire et Tissulaire

19962001

Université de Caen

Doctor of Philosophy (PhD), Cellular and tissular biology

19921996

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