Bharat Gawande profiles

  • 2 of 2 profiles
  1. Bharat Gawande

    Title
    Senior Scientist at SomaLogic
    Demographic info
    Greater Denver Area | Biotechnology
    Current
    Senior Scientist at SomaLogic
    Past
    Scientist II at SomaLogic, Scientist I at SomaLogic
    Education
    University of Colorado Boulder, National Chemical Laboratory, Pune, India, University of Pune
    Summary
    Over 20 Years of experience in the molecular biology, microbiology and biotechnology research in renowned academic and biotech industry for basic, industrial, diagnostic and therapeutic applications. Developed improved Systematic Evolution of Ligands by EXponential enrichment (SELEX) combinatorial method for selection of specific high affinity modified ligands for diagnostic and therapeutic applications. Detailed proven expertise in all aspects of modified aptamer discovery process. Conducted several high-throughput SELEX experiments against hundreds of human protein targets to discover SOMAmers (Slow Off-rate Modified Aptamer) to be used in SOMAscan assay- proprietary multiplexed proteomic aptamer-based biomarker discovery platform. Conducted many SELEX projects against high value diagnostic and therapeutic targets for leading Biotech/ Biopharmaceutical partner research collaboration projects. Conducted post-SELEX optimization experiments on potential therapeutic SOMAmers to improve their in vivo nuclease stability and reduce chemical synthesis costs (truncation's, mod replacement, 2' substitutions etc). Evaluated candidate and lead therapeutic SOMAmers for efficacy in functional in vitro activity assays (inhibition assays) Executed SOMAmer pharmacokinetic (PK) experiments in RAT in vivo model, processed samples, and analysed PK data for developing SOMAmer therapeutics in autoimmune and chronic inflammatory indications.
    Bharat Gawande
  2. Bharat Gawande

    Title
    Student at Nagpur University
    Demographic info
    Chandrapur Area, India | Computer Software
    Education
    Rajiv Gandhi College Of Engineering Research & Technology, Nagpur University
    Bharat Gawande