Christopher Wassman

Christopher Wassman

Software Engineer at Google

Location
San Francisco Bay Area
Industry
Computer Software

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Christopher Wassman's Overview

Current
Past
  • Software Engineer at Outcome.com
  • Web Developer at Pacific Bell Internet Services
  • Systems Administrator at Northwestern University
Education
Connections

157 connections

Christopher Wassman's Summary

Same goal as every year, to take over the world.

Specialties

Bit twiddling.

Christopher Wassman's Experience

Software Engineer

Google

January 2011Present (3 years 9 months)

Postdoctoral Researcher

UC Irvine

20102012 (2 years)

Research Assistant

UC Irvine

20022010 (8 years)

Founding Software Engineer

Blue Titan Software

June 2001November 2003 (2 years 6 months)

Software Engineer

Outcome.com

September 2000June 2001 (10 months)

Web Developer

Pacific Bell Internet Services

August 1999September 2000 (1 year 2 months)

Systems Administrator

Northwestern University

September 1996June 1999 (2 years 10 months)

Christopher Wassman's Publications

  • Ensemble-based Computational Approach Discriminates Functional States of p53 Activity

    • PLOS Comput. Biol.
    • 2011
    Authors: Christopher Wassman, Faezeh Salehi, Ozlem Demir, Roberta Baronio, Linda Hall, G. Wes Hatfield, Richard Chamberlin, Peter Kaiser, Richard Lathrop, Rommie E. Amaro
  • Computational identification of a transiently open L1/S3 pocket for reactivation of mutant p53

    • Nature Communications
    • January 29, 2013

    LinkedIn only allows 10 authors (I've listed the first authors in their entires). Here is the full author List:

    Christopher D. Wassman, Roberta Baronio, Özlem Demir, Brad D. Wallentine, Chiung-Kuang Chen, Linda V. Hall, Faezeh Salehi, Da-Wei Lin, Benjamin P. Chung, G. Wesley Hatfield, A. Richard Chamberlin, Hartmut Luecke, Richard H. Lathrop, Peter Kaiser & Rommie E. Amaro

    The tumour suppressor p53 is the most frequently mutated gene in human cancer. Reactivation of mutant p53 by small molecules is an exciting potential cancer therapy. Although several compounds restore wild-type function to mutant p53, their binding sites and mechanisms of action are elusive. Here computational methods identify a transiently open binding pocket between loop L1 and sheet S3 of the p53 core domain. Mutation of residue Cys124, located at the centre of the pocket, abolishes p53 reactivation of mutant R175H by PRIMA-1, a known reactivation compound. Ensemble-based virtual screening against this newly revealed pocket selects stictic acid as a potential p53 reactivation compound. In human osteosarcoma cells, stictic acid exhibits dose-dependent reactivation of p21 expression for mutant R175H more strongly than does PRIMA-1. These results indicate the L1/S3 pocket as a target for pharmaceutical reactivation of p53 mutants.

Christopher Wassman's Skills & Expertise

  1. Machine Learning
  2. Software Engineering
  3. Distributed Systems
  4. Computer Science
  5. SOA
  6. randomkeywordstuffing
  7. Structural Bioinformatics
  8. MapReduce
  9. Web Services
  10. XML
  11. Linux
  12. Databases
  13. Java
  14. PHP
  15. Web Applications
  16. Oracle
  17. Python
  18. Algorithms

Christopher Wassman's Patents

Christopher Wassman's Education

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