Silvia Enders-Wognum

Highly motivated biomedical engineer looking to apply academic and analytical engineering skills to biomedical problems.

Eindhoven Area, Netherlands

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Silvia Enders-Wognum's Overview


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Silvia Enders-Wognum's Summary

Highly motivated researcher looking for a new challenge in biomedical engineering. My professional objective is to apply analytical engineering skills to complex and challenging biomedical research problems.

My postdoc position at the department of Radiotherapy of the Academic Medical Center (AMC) in Amsterdam recently ended due to ending funding.
My research focused on utilizing deformable image registration techniques to quantify bladder deformation and tumor displacement. As a result of bladder filling, the delivered dose is most likely not equal to the planned dose. Anatomically accurate registration between (Cone Beam) CT images of different moments in time is a prerequisite for assessment of the actually delivered dose and eventually to improve bladder cancer radiation. The project is funded by General Electric Company (GE).

After obtaining my MSc in Biomedical Engineering at the Eindhoven University of Technology in The Netherlands, I pursued PhD in the Department of Bioengineering at the University of Pittsburgh in Pittsburgh, PA, USA.
My PhD research focused on modeling soft tissue remodeling, applied to the urinary bladder post-spinal cord injury. It involved developing a composite constitutive model of the urinary bladder wall, deriving growth and remodeling equations to describe bladder tissue remodeling, and applying these models to bladder remodeling events as a result of a change in mechanical environment after spinal cord injury.

Specialties: Medical Physics, Biomedical Engineering, Radiotherapy;
Urological and orthopedic applications;
Image registration, Soft tissue biomechanics, Constitutive modeling;
Utilizing engineering concepts to solve biomedical research problems, Analytical problem solving, Working in a multi-disciplinary environment, Public speaking.

Silvia Enders-Wognum's Experience

Postdoctoral Researcher


Privately Held; 5001-10,000 employees; Hospital & Health Care industry

September 2010May 2014 (3 years 9 months) Amsterdam Area, Netherlands

My research project at the Radiotherapy Physics department of the AMC, funded by General Electric, focused on deformable image registration to obtain quantitative information on organ deformation (e.g. pancreas, intestines, bladder) from planning CT scans. This information can be used to optimize Image Guided Adaptive Radiotherapy (IGART) such that a more accurate region around the tumor can be subjected to radiation while minimizing radiation of surrounding organs.

Graduate Student Researcher

University of Pittsburgh

Educational Institution; 10,001+ employees; Higher Education industry

September 2005September 2010 (5 years 1 month)

My research involves developing a structural constitutive model that elucidates key remodeling mechanisms in the urinary bladder wall after spinal cord injury. Specifics:
• Determining the planar biaxial mechanical properties of decellularized rat urinary bladder wall.
• Developing a Matlab tool to perform curve fitting on mechanical data to various constitutive models.
• Analyzing and compiling available mechanical and biochemical data of rat bladder remodeling.
• Combining newly derived kinetic remodeling equations with a structural constitutive model and calibrating the model with available and newly obtained experimental data.
• Supervising undergraduate students from various engineering and science disciplines.
• Reviewer for the Journal of Biomechanical Engineering.

Educational Institution; 1001-5000 employees; Research industry

January 2005June 2005 (6 months)

I performed a feasibility study for the development of a swelling intervertebral disc prosthesis.

Educational Institution; 1001-5000 employees; Research industry

September 2003November 2004 (1 year 3 months)

For my master's thesis, I investigated the influence of decreasing osmotic pressure on the opening of existing cracks in swelling materials like hydrogel and intervertebral disc tissue, using an experimental hydrogel model and a numerical quadriphasic mixture model.

Research published in Spine, see website link below.

Educational Institution; 1001-5000 employees; Research industry

February 1999September 2003 (4 years 8 months)

Giving information to final year high school students about the Eindhoven University of Technology.

Research Intern

McGill University

Educational Institution; 10,001+ employees; Higher Education industry

April 2003August 2003 (5 months)

At the Orthopaedic Research Laboratory of McGill University in Montreal, Canada, I worked on determining the optimal center of rotation of a novel functional intervertebral disc replacement using mechanical testing on cadaveric spines.

Silvia Enders-Wognum's Publications

Silvia Enders-Wognum's Skills & Expertise

  1. Biomechanics
  2. Image Registration
  3. Biomedical Engineering
  4. Research
  5. Medical Research
  6. Public speaking
  7. Science
  8. Analytical problem solving
  9. Medical Physics
  10. Working in a multi-disciplinary environment
  11. Experimentation
  12. Cell
  13. Physics
  14. Bioengineering

Silvia Enders-Wognum's Volunteer Experience & Causes

  • Volunteer Interests

    • Causes I care about:

      • Education
      • Health
      • Science and Technology

Silvia Enders-Wognum's Projects

  • Deformable matching techniques

    • September 2010 to Present

    Deformable matching techniques are a prerequisite for effective dose accumulation during radiotherapy ("which part of an organ gets how much dose"). In this project we develop methods for adequate deformable matching techniques special interest for the anatomical accuracy.
    Sponsor: General Electric

Silvia Enders-Wognum's Education

University of Pittsburgh

PhD, Bioengineering


• Dissertation title: A structural constitutive model for insights into key remodeling phenomena in soft tissues. Advisor: Dr. Michael S. Sacks.
• Relevant coursework: Biomechanics of organs, tissues and cells; Finite element analysis; A systems approach to inflammation (see link below of resulting paper published in PLoS ONE); Advanced Biomaterials.
• Workshop: Engineering in Urology, two-day intensive course on the role of technology and engineering in urology. University of Minnesota, Minneapolis, MI, USA, April 17 - 18, 2006.

Eindhoven University of Technology

BSc, MSc, Biomedical Engineering


• Master’s thesis title: Decreasing osmotic pressure as a cause of intervertebral disc herniation – An experimental and numerical model study. Supervisor: Dr. Jacques M. Huyghe.
• Relevant coursework: Advanced numerical analysis of continua; Biological mixtures; Bone mechanics; Modern drug development, a two-week course at Organon BioSciences N.V.,Oss, The Netherlands.

Activities and Societies: Chairperson, member of several committees, and member of ESDV Footloose (ballroom dancing); joined founder and chairperson of Stichting Scala (cultural umbrella organization); member of the board and member of VV Tamar (volleybal),

Goois lyceum


Silvia Enders-Wognum's Languages

  • English

    (Full professional proficiency)
  • French

    (Elementary proficiency)
  • German

    (Elementary proficiency)

Silvia Enders-Wognum's Additional Information

Honors and Awards:

2nd place in student presentation competition. 43rd Annual Technical Meeting of the Society of Engineering Science, Pennsylvania State University, PA, USA, August 13 - 16, 2006

Poster award (3rd place) in MS Student Paper Competition; Solids, Design and Rehabilitation I Category; 2005 ASME Summer Bioengineering Conference, Vail, CO, USA, June 22 - 26, 2005

Fulbright sponsorship granted for graduate studies at the University of Pittsburgh. April 2005.

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