Robert Marc

Current

• President and CEO at Signature Immunologics
• Professor of Ophthalmology at University of Utah

Past

• Asstistant, Associate, & Full Professor of Neural Sciences at University of Texas Health Science Center at Houston

Education

• The University of Texas Health Science Center at Houston
• The University of Texas at El Paso
• University of Texas at El Paso

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Connections

18 connections

Industry

Biotechnology

Websites

• MarcLab Website
• Signature Immunologics

Robert Marc’s Summary

My global objectives are the development of imaging strategies and molecular probes designed to reveal cellular physiological states and large-scale neural systems reconstruction. The current focus is computational molecular phenotyping: a system of analysis based on anti-hapten molecular detection, high-density sample array fabrication, multidimensional image processing and computational pattern recognition analyses for image segmentation. I have developed a library of >60 small-molecule probes (including probes to the free states of 20 natural amino acids as well as glutathione, taurine, etc; and a set of exogenous probe molecules) to map cellular metabolic signatures, transport and channel permeation. The latter employs organic cation probes and detection to map functional glutamate signaling in the retina and brain. Applications of this technology include high-throughput phenotyping, pharmacological response assays, and cellular metabolic profiling. We have also discovered unprecedented plasticity and rewiring in the neural retina in advanced degenerative diseases; phenomena that change strategies for retinal rescue via genetic, molecular, cellular or bionic means. I have also founded a startup company, Signature Immunologics Inc, that provides a library of small molecule probes and continues to explore strategies for commercialization of anti-hapten methods. Finally, we are undertaking the largest ultrastructural neural systems reconstruction yet attempted.

Robert Marc’s Specialties:

Neural remodeling in retinal degenerations
Comprehensive molecular mapping of ganglion cells
EM-LM molecular mapping
Metabolic mapping probes
Ion channel activity mapping
First CMP of a disease process
Signature Immunologics established
Computational molecular phenotyping (CMP)
Functional mapping of vertebrate cone mosaics

Robert Marc’s Experience

• President and CEO

  Signature Immunologics

  (Biotechnology industry)

  1996 — Present (13 years )

• Professor of Ophthalmology

  University of Utah

  (Educational Institution; 10,001 or more employees; Higher Education industry)

  1993 — Present (16 years )

• Asstistant, Associate, & Full Professor of Neural Sciences

  University of Texas Health Science Center at Houston

  (Higher Education industry)

  1978 — 1993 (15 years )

Robert Marc’s Education

• The University of Texas Health Science Center at Houston

  PhD , Neuroscience , 1971 — 1975

• The University of Texas at El Paso

  BSc , Biology , 1967 — 1971

• University of Texas at El Paso

  BSc, Honors , Biology , 1967 — 1971

Additional Information

Robert Marc’s Websites:

• MarcLab Website
• Signature Immunologics

Robert Marc’s Interests:

Vision, retinal circuitry, metabolomics, optical imaging, pattern recognition, EM

Robert Marc’s Groups:

AAAS, Assoc Research in Vision and Ophthalmology, Society for Neuroscience

Robert Marc’s Honors:

2008...present: Calvin & JeNeal Hatch Presidential Endowed Chair, Univ Utah
2003...2008: Mary H. Boesche Professorship, Univ Utah
1993...2001: Jules & Doris Stein RPB Professor, Univ of Utah
1986...1993: Robert Greer Professor, Univ Texas Grad Sch Biomed Sciences
1976: Glenn Fry Award, American Academy of Optometry
1967...1971: Stevens Scholar and B.Sc. Honors, University of Texas at El Paso

Robert Marc’s Contact Settings

Interested In:

• new ventures
• job inquiries
• expertise requests
• business deals
• reference requests
• getting back in touch