
PhD Student at Max Planck Institute for Developmental Biology, Tübingen, Germany
Stuttgart Area, Germany

PhD Student at Max Planck Institute for Developmental Biology, Tübingen, Germany
Stuttgart Area, Germany
How are complex organs formed? Plants provide an incredible system to better understand this and many of the most fundamental questions in development.
I'm working on untangling a major developmental transition in angiosperms, the reproductive transition to flowering. By using full genome scale ChIP-chip, ChIP-seq, and other microarray platforms, I'm discovering the direct targets of the transcription factors that govern this transition.
microarray technology, various molecular virology, cellular immunology, and molecular biology techniques, QPCR expression analysis, chromatin immunoprecipitation, managment skills, mountain biking and rock climbing
(Research industry)
October 2006 — Present (2 years 10 months)
I'm really interested in the genetic regulatory networks that control major developmental transitions in various organisms.
Right now, I'm employing novel genome scale approaches (ChIP-seq, ChIP-chip, other microarray platforms) to disentangle the gene regulatory network involved in the crucial reproductive transition to flowering. I find this of extreme interest, as we are approaching this network both from the perspective of direct repressors and promoters of the transition to gain a comprehensive understanding of the structure of a complex, yet tractable regulatory network.
Aside from science, I love to ride bikes and of course read!
Yant LJ, Mathieu J, Schmid M. Just Say "no"; floral repressors help Arabidopsis bide the time. Current Opinion in Plant Biology in review
Mathieu J, Yant LJ, Mürdter F, Küttner F, Schmid M. Repression of flowering by the miR172 target SMZ. PLoS Biology in press
(Educational Institution; 10,001 or more employees; Higher Education industry)
August 2003 — October 2006 (3 years 3 months)
Discovery of associations of MHC class I alleles with reduced AIDS virus replication in vivo, and detailed immunologic characterizations
Selected papers (of 5):
Yant LJ, Friedrich TC, Johnson RC, May G, Maness NJ, Lifson J, O’Connor DH, Carrington M, Watkins DI. The High Frequency MHC Class I Allele Mamu-B*17 is Associated with Control of SIVmac239 Replication J.Virol 2006; 80(10)
Wojcechowskyj JA,.Yant LJ,.Wiseman RW, and O’Connor DH. Control of SIVmac239 is not predicted by inheritance of Mamu-B*17-containing haplotypes. J.Virol. 2007; 81
Maness NJ, Yant LJ, Chung C, Friedrich TC, May GE, Soma T, Leon EJ, Wilson NA, Piontkivska H, Hughes AL, Sidney J, Sette A, Watkins DI. Comprehensive immunological evaluation of elite controller and progressor Mamu-B*17-positive SIV-infected rhesus macaques reveals surprisingly few differences. J Virol in press
Patent:
“Novel Approach to Broaden and Strengthen Cellular Immune Responses for a Global AIDS Vaccine"
(Educational Institution; 10,001 or more employees; Higher Education industry)
2001 — 2004 (3 years)
Selected papers (of 7)
Yant LJ, Ran Q, Rao L, Van Remmen H, Shibatani T, Belter JG, Motta L, Richardson A, Prolla TA. The selenopotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. Free Radic Biol Med. 2003 Feb 15;34(4):496-502
Friedrich TC, Dodds E, Yant LJ, Rudersdorf R, Cullen C, Evans ET, Desrosiers RC, Mothé BR, Sidney J, Sette A, Kunstman K, Wolinsky S, Piatak M, Lifson J, Wilson N, O’Connor DH, Watkins DI. Reversion of cytotoxic T-lymphocyte (CTL) escape variant immunodeficiency viruses in vivo. Nature Medicine 2004 Mar;10(3):275-81.
Friedrich TC, Frye CA, Yant LJ, O’Connor DH, Kriewaldt N, Benson M, Dodds EJ, Cullen C, Rudersdorf R, Hughes AL, Wilson N, Watkins DI. Extra-epitopic compensatory substitutions restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic T-lymphocyte response. J.Virol 2004 Mar;78(5):2581-5.
PhD , Developmental Genetics , 2006 — 2009
Master of Science , Pathology , 2004 — 2006
Master of Arts , History of Philosophy , 2001 — 2004
Bachelor of Arts , Classics, Biochemistry , 1996 — 2000
Climbing and cycling.
magna cum laude, various fellowships, that whole shtick.