
Ph.D. candidate at the Centre for Systems Biology, Samuel Lunenfeld Research Institute, University of Toronto
Toronto, Canada Area

Ph.D. candidate at the Centre for Systems Biology, Samuel Lunenfeld Research Institute, University of Toronto
Toronto, Canada Area
• soon-to-be PhD-holder with strong expertise in research, analysis, and project management.
• strong written communication skills from experience preparing a variety of documents: policy statements, position papers, briefing notes, press releases, formal letters, meeting minutes, grant proposals, and scientific manuscripts.
• strong oral communication skills from experience serving on a variety of boards and committees, and from presenting PowerPoint decks on a variety of topics (scientific research, public policy) to a variety of audiences (scientific researchers, government decision-makers, university officials, and the general public).
(Biotechnology industry)
October 2008 — Present (1 year 2 months)
• invited to write commentaries on science policy for MaRS – a non-profit organization focused on maximizing the economic and social impact of Canadian science and technology innovation, by fostering collaboration between academic science, business and capital
• published online articles:
Budget S&T draws mixed reviews
http://blog.marsdd.com/2009/02/03/budget-st-draws-mixed-reviews/
Are we producing too many scientists?
http://blog.marsdd.com/2008/11/04/are-we-producing-too-many-scientists/
The politicization of science in Canada
http://blog.marsdd.com/2008/10/16/the-politicization-of-science-in-canada/
(Non-Profit; Public Policy industry)
September 2008 — Present (1 year 3 months)
• as part of an 18-member team of organizers, developed the aims and scope of Canada’s first in-depth, national-level, multi-sector, multi-disciplinary conference devoted to science policy (http://sciencepolicy.ca)
• drafted the conference’s 30-page Strategic Plan, including an environmental scan to identify a network of ~130 Canadian science policy stakeholders from the government, academic, industry, and non-profit sectors
• drafted a grant proposal to the Canadian Institutes of Health Research (CIHR) that was subsequently funded with the maximum award of $25,000
• prepared and presented PowerPoint decks to: the Parliamentary Assistant to the Ontario Minister of Training, Colleges and Universities; the Vice-President, Research, of the University of Toronto; and 2 general meetings of conference volunteers
• prepared formal correspondence for the Chair's signature (to CEOs, Presidents, Directors, etc)
• drafted press releases and conference announcements
• offered updates and input at 29 Organizing Committee meetings
(Public Policy industry)
September 2008 — Present (1 year 3 months)
• with one co-founder, started a website tracking science policy in Canada’s political arena and media (http://sciencecanada.blogspot.com)
• posted links to ~3,500 press articles and editorials dealing with Canadian public policy in the realms of scientific research and innovation, health, energy, and the environment
(Publishing industry)
June 2008 — Present (1 year 6 months)
• as part of an 8-member team of Senior Editors, handled the operations of Hypothesis – a peer-reviewed, open-access scientific journal run entirely by a volunteer editorial staff (http://www.hypothesisjournal.com)
• wrote the journal’s editorial policies on: authorship, conflicts of interest, peer review, editorial decisions, redundant publication, media relations, confidentiality, response to allegations of scientific misconduct, corrections & retractions, correspondence, editorial independence, access to data & materials, advertising, and human & animal research
• wrote the journal’s Copyright & License Agreement
• wrote the journal’s Instructions for Authors
• copy-edited 9 manuscripts
• coordinated the peer review of 2 manuscripts
• offered updates and input at 6 Editorial Board meetings
(Public Policy industry)
May 2008 — Present (1 year 7 months)
• as part of a 7-member senior executive, guided the research and publishing activities of the CSA – a public policy think-tank promoting church-state separation and the neutrality of government in matters of religion (http://www.secularalliance.ca)
• wrote 6 briefing notes and 5 policy position papers on a variety of topics, including: constitutional law, human rights law, charity law, education policy, and philosophy of science
• directed the activities of a 14-member ad-hoc committee of volunteer researchers
• archived and posted links to ~3,100 press articles and editorials dealing with Canadian public policy in the realm of religious freedom
• reviewed ~700 pages of secondary-school science education materials to evaluate their scientific rigour and consistency with Ontario Ministry of Education policy
• recorded and prepared minutes for 21 Board of Directors meetings
• prepared and presented a PowerPoint deck at the 2009 Centre for Inquiry Canada Annual General Meeting
• handled ~75 information / membership inquiries from the public
(Public Policy industry)
May 2008 — Present (1 year 7 months)
• offered proposal-writing expertise to the FAC – a registered charitable organization promoting public education about critical thinking and scepticism (http://freethoughtassociation.ca)
• wrote 2 grant proposals for submission to external funding agencies
• offered updates and input at 17 Board of Directors meetings
(Non-Profit; Think Tanks industry)
May 2008 — Present (1 year 7 months)
• volunteered to help run special events organized by the CFIO – a registered charitable organization promoting evidence-based inquiry into science, pseudoscience, medicine, and ethics (http://www.centerforinquiry.net/ontario)
• assisted in the set-up and operation of 13 public lectures on topics at the interface of science and society; performed various duties, including: introducing speakers; moderating Q&A periods with the audience; handling sale of tickets, books, and magazines; representing the organization in interactions with the public
(Biotechnology industry)
September 2002 — Present (7 years 3 months)
Mike Tyers' lab, Centre for Systems Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital; and Department of Molecular Genetics, University of Toronto, Canada (http://www.mshri.on.ca/tyers)
• systematically mapped nutrient-sensing and growth-control pathways in the model organism S. cerevisiae by integrating genome-wide data on phenotypes, subcellular localization, transcript abundance, protein-protein interactions, DNA-protein interactions, and genetic interactions
• constructed a system for small-molecule control of protein function based on fusion to ligand-binding domains
(Pharmaceuticals industry)
January 2002 — May 2002 (5 months)
Apoptosis Group, Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, QC
• characterized the in-vitro protease activity of a newly-cloned caspase-12 homologue from rat against fluorogenic tetrapeptide and radiolabeled protein substrates
• produced a variety of recombinant human caspases for small-molecule screening assays and polyclonal antibody generation, via their high-level expression and purification from E. coli
(Public Company; Pharmaceuticals industry)
May 2001 — August 2001 (4 months)
Apoptosis Group, Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Kirkland, QC
(Government Agency; Government Administration industry)
September 2000 — December 2000 (4 months)
Human Parvovirus B19 Group, Division of Blood-borne Pathogens, Health Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, MB
• assisted in a yeast two-hybrid screen of a human cDNA library to identify novel protein interaction partners for the viral non-structural protein (NS1)
• studied the ability of transfected NS1 to induce apoptosis in human erythroid cell lines by assaying for DNA fragmentation and caspase activation
(Pharmaceuticals industry)
January 2000 — April 2000 (4 months)
Human Immunodeficiency Virus (HIV) Group, Department of Biological Sciences, Boehringer Ingelheim (Canada) Ltd., Bio-Méga Research Division, Laval, QC
• assisted in the bacterial expression and purification of HIV-1 reverse transcriptase (RT) for high-resolution X-ray crystallographic study, using FPLC and ion-exchange, gel filtration, and affinity chromatography
• performed high-throughput in-vitro enzymatic assays to identify small-molecule inhibitors of HIV-1 RT using the Biomek automated robotic workstation and scintillation proximity assay (SPA) technology
(Pharmaceuticals industry)
January 1999 — April 1999 (4 months)
Human Papillomavirus (HPV) Group, Department of Biological Sciences, Boehringer Ingelheim (Canada) Ltd., Bio-Méga Research Division, Laval, QC
• assisted in the optimization of an in-vitro assay to identify small-molecule inhibitors of the E1 helicase of human papillomavirus
• performed a variety of microplate-format ELISAs and protein-DNA binding assays to screen for inhibitors of other HPV enzymes
Ph.D. , Molecular Genetics , 2002 — 2010 (expected)
• cumulative average: A+
• Terry Fox Foundation Research Studentship [2006-2008]
- one of 13 studentships of $47,000 awarded Canada-wide by the National Cancer Institute of Canada (NCIC) biomedical panel.
• NSERC Canada Graduate Scholarship (CGS-D) [2004-2006]
- one of 148 scholarships of $70,000 awarded Canada-wide by the Natural Sciences and Engineering Research Council (NSERC) for pursuit of doctoral studies.
• NSERC Post-Graduate Scholarship A (PGS-A) [2002-2004]
- one of 626 scholarships of $34,600 awarded Canada-wide by the Natural Sciences and Engineering Research Council (NSERC) for pursuit of masters studies.
B.Sc. , Specialized Honours Co-op Biochemistry , 1997 — 2001
• cumulative average: 94.7%
• Governor General’s Academic Silver Medal [2002]
- awarded to the graduating student with the highest university-wide cumulative average of any student in any discipline.
SELECTED PUBLICATIONS
Sharom JR (2008). The scientific workforce policy debate: Do we produce too many biomedical trainees? Hypothesis. 6:17.
Bøe CA*, Garcia I*, Pai CC*, Sharom JR*, Skjølberg HC*, Boye E, Kearsey S, Macneill SA, Tyers MD, Grallert B (2008). Rapid regulation of protein activity in fission yeast. BMC Cell Biol. 9:23.
* contributed equally and share first authorship
Roy S*, Sharom JR*, Houde C, Loisel TP, Vaillancourt JP, Shao W, Saleh M, Nicholson DW (2008). Confinement of caspase-12 proteolytic activity to autoprocessing. Proc Natl Acad Sci U S A. 105:4133.
* contributed equally and share first authorship
Jorgensen P, Rupes I, Sharom JR, Schneper L, Broach JR, Tyers M (2004). A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 18:2491.
Sharom JR, Bellows DS, Tyers M (2004). From large networks to small molecules. Curr Opin Chem Biol. 8:81.