James Poleman

Technician IV at Case Western Reserve University

Location: Cleveland/Akron, Ohio Area
Industry: Research

As a LinkedIn member, you'll join 150 million other professionals who are sharing connections, ideas, and opportunities. And it's free! You'll also be able to:

See who you and James Poleman know in common
Get introduced to James Poleman
Contact James Poleman directly

View Full Profile

James Poleman's Overview

Current

Tech IV at Case Western Reserve University

Connections

41 connections

Websites

I'm interested in splitting time between New Orleans & Cleveland.

Though the restaurant scene is booming in Cleveland, I think I have a concept that will compete on the East side. My experience is in science, but I have been peripherally associated with restaurants for 20 years. I would be interested in talking to a culinarily wise and experienced investment partner.

Tech IV

Case Western Reserve University

Educational Institution; 5001-10,000 employees; Higher Education industry

August 2000 – Present (11 years 7 months)

Molecular Biology in a Pediatrics / Genetics laboratory.

Given complete autonomy to create and carry out projects of my own interest as well as that of my supervisor.

Current work seeks to reveal the cause of the disparity in size and body mass index between those with Cystic Fibrosis (CF) and "normal" people. Small size for age has been shown to be an independent risk factor for decline in pulmonary function. Therefore, correcting CF growth retardation should decrease mortality from the disease.

Methods used to this end include manipulation of mouse models, both genetically and nutritionally; examining energy expenditure through metabolic biochemistry as well as growth hormone pathways and pituitary function. Cachexia from lung infection and loss of exocrine pancreatic function are also considered.

A secondary project funded by the Cystic Fibrosis Foundation explores possible new biomarkers for the disease (and its correction) that can be assayed in a manner simpler than the present battery of lung function and electrophysiology tests.

Supervised by Mitchell Drumm, Ph.D, who in 1990 worked with Francis Collins, M.D., Ph.D. (Now Director of N.I.H.), on identification of the gene causing Cystic Fibrosis.