Experienced Synthetic Organic Postdoc looking for a Permanent Position in the Pharmaceutical Industry.
South Bend, Indiana Area
Experienced Synthetic Organic Postdoc looking for a Permanent Position in the Pharmaceutical Industry.
South Bend, Indiana Area
Total synthesis of marine natural products. Design, execution, & optimization of multi-step synthetic organic pathways. Proficient in handling air & moisture sensitive reagents. Nucleosides. Nucleotides. Amines. Thiols. Pyrroles. Porphyrins. Modern compound separation and purification techniques (TLC, flash column chromatography, MPLC, HPLC). Isolation of novel, low-abundant, marine natural products (0.0001 mass % each). Operation & interpretation of NMR (1H, 13C, 1D, 2D), IR, GC, MS, UV-Vis, & gel electrophoresis. Solving & interpretation of protein crystal structures. Protein crystallization. Technical writing and presentations. Supervision. Proficient in the use of MS Office, Chemdraw, MestRe-C, ACD/Labs, Scifinder, & Beilstein. Expert knowledge about the application and interpretation of DNA testing for genealogical purposes (Genetic Genealogy). Professional scientific consultation service. Translation service from German to English. Reading knowledge of Russian. Native speaker of German.
● Accomplished the total synthesis of a marine natural product.
● Extensive experience & skills in the design & execution of multi-step synthetic organic sequences utilizing modern synthetic methodology.
● Isolated novel low-abundant (0.0001 mass %) marine natural products.
● Proficient in scientific problem solving & innovation; experienced with instrumentation.
● Excellent collaboration, oral & written communication, & interpersonal skills.
● Supervising, mentoring, & teaching experience.
(Pharmaceuticals industry)
2007 — Present (1 year)
● Professional scientific consultation service.
● Translation service from German to English.
(Educational Institution; Pharmaceuticals industry)
2002 — Present (6 years)
● Completed the total synthesis of the marine natural product iejimalide B.
● Developed improved synthetic routes to target structures.
● Applied the Shiina macrolactonization to the formation of a 24-membered macrolactone, which is the largest ring closed by a Shiina macrolactonization reported to date.
● Established an efficient Pt-catalyzed hydroboration of complex molecules.
● Synthesized iejimalide derivatives to establish structure-activity relationship (SAR).
● Synthesized an iejimalide-fluorophore conjugate which allowed cellular localization study.
● Isolated highly anti-tumor active marine natural products by flash chromatography and HPLC from a crude tunicate acetone extract.
● Trained, guided, and supervised undergraduate research students.
● Took responsibility for maintaining lab equipment and training new graduate students.
● Presented results at meetings and wrote papers.
(Educational Institution; Pharmaceuticals industry)
2001 — 2002 (1 year)
● Synthesized alkylated and phosphorylated nucleosides for use in NMR studies.
● Synthesized linked fluorophore-amine molecules.
● Developed new synthetic routes to target structures.
● Managed database of compounds that were submitted for biological testing.
● Trained, guided, and supervised undergraduate research students.
● Took responsibility for maintaining lab equipment and training new graduate students.
(Pharmaceuticals industry)
1995 — 1996 (1 year)
● Crystallized thermolysin mutants.
● Solved and refined protein crystal structures and collected data at a synchrotron.
(Educational Institution; Research industry)
1993 — 1994 (1 year)
● Synthesized and characterized macrocyclic compounds and their metal complexes.
(Educational Institution; Pharmaceuticals industry)
1993 — 1993 (less than a year)
● Isolated and purified natural products using HPLC.
Ph.D., Chemistry, 1996 — 2001
● Synthesized model compounds of the active site of the metalloenzyme nitrile hydratase. These were Fe and Co complexes in a mixed nitrogen/sulfur coordination sphere.
● Designed new ligands and developed new synthetic routes to target structures.
● Presented results at meetings and wrote papers.
● Took responsibility for maintaining lab equipment and training new graduate students.
● Trained, guided, and supervised undergraduate research students.
● Taught organic and introductory classes and laboratories.
Research for Diplom-Chemiker (German M.S. in Chemistry), Organic Chemistry, 1994 — 1995
● Designed and synthesized novel pyrroles, oligopyrroles, and expanded porphyrins.
Diplom-Chemiker (German M.S. in Chemistry), Chemistry, 1990 — 1995
Chemistry, Science in General, Reading, Running, Traveling, Archaeology, Genetic Genealogy
Member, American Chemical Society (ACS)
Member, German Chemical Society (Gesellschaft Deutscher Chemiker, GDCh)
Member, International Society of Genetic Genealogy (ISOGG)
I am now looking for a permanent Research Scientist Position in the pharmaceutical, chemical, or biotechnology industry: please contact me with all relevant opportunities anywhere on the Planet, preferably in either Europe (Switzerland, UK, Germany, etc.), Canada, or the United States. Thank you!
dirk_schweitzer at yahoo dot com