
Greater Boston Area

Greater Boston Area
Bioinformatics software programming using Perl, C, C++.
Web site development using Linux, Apache, Perl or PHP, MySQL or Oracle.
Data analysis using R.
(Public Company; MON; Biotechnology industry)
May 2006 — Present (3 years 3 months)
I lead a team of four that develops and maintains bioinformatics software and laboratory information management software (LIMS) for support of the high-throughput mutagenesis, expression, and assay of proteins.
(Biotechnology industry)
August 2005 — January 2006 (6 months)
I configured and customized the open source BioArray Software Environment for a Massachusetts transcription profiling startup.
I revised SSAHA (Sequence Search and Alignment by Hashing Algorithm) open source code so it could be compiled by modern GCC compilers, and I debugged the software so it would run correctly on PowerPC-based Macintosh computers. See <http://sphaerula.com/legacy/SSAHA/> for more information.
(Biotechnology industry)
February 2003 — July 2005 (2 years 6 months)
Agilix Corporation was a startup company that was working to commercialize two products, a unique transcriptional profiling technology, and a labeling technique used for protein analysis using mass spectrometry.
I managed bioinformatics and data analysis projects and performed data analysis in support of Agilix’s GenCompass transcriptional profiling technology in human, dog, mouse, rat, and other species, using Perl, C, R, and SQL tools under Unix/Linux, Mac OS X, and Windows. See Roth et al. 2004. Expression profiling using a hexamer-based universal microarray. Nat. Biotechnol. 22:418-426.
(Privately Held; 11-50 employees; Biotechnology industry)
September 2004 — February 2005 (6 months)
Cantata was a startup company that was using mass spectrometry for the profiling of small metabolic compounds for diagnostics and drug development. I designed and implemented a database for storing and querying metabolic profiling data. I was the primary writer of a company white paper on metabolic profiling and of an SBIR grant proposal. Cantata closed in May, 2004.
(Privately Held; 51-200 employees; Biotechnology industry)
March 2001 — June 2002 (1 year 4 months)
Cereon Genomics was a subsidiary of Monsanto Company that was located in Cambridge, Massachusetts. Cereon carried out research in plant and bacterial genomics, transcriptional profiling, and metabolic profiling. Cereon was closed at the end of June, 2002.
Created Monsantos first database for storing transcriptional profile data and annotation, and built a web interface with links to other Monsanto databases using Oracle and Perl CGI
Created a cDNA sequence confirmation pipeline using Perl, C, C++, and SQL in support of the nylon array transcription profiling group
Analyzed the genome of Agrobacterium tumefaciens to identify horizontally transferred DNA segments and coauthored genome paper
(Public Company; 10,001 or more employees; MON; Biotechnology industry)
November 1993 — February 2001 (7 years 4 months)
Bioinformatics Project Lead (Sep. 1998Feb. 2001)
Overhauled the EST processing pipeline and reprocessed data to increase quality and accuracy, then ran and maintained the pipeline through Dec. 2001
Provided special analysis of subsets of EST data in support of research projects
Project manager of genomics patents for six-person team (Sep. 1998Aug. 2000)
Generated high-volume genomics patent applications
Provided data analysis for plant metabolic pathway patent applications
Computational Molecular Biologist (Nov. 1993Aug. 1998)
Installed and maintained Monsantos DNA construct database and GCGs Wisconsin Package software, and wrote custom software for bioinformatics analysis
Provided user training and support for 200 users at seven Monsanto sites, including scientists in Monsantos pharmaceutical subsidiary, G. D. Searle
(Educational Institution; Research industry)
May 1989 — August 1993 (4 years 4 months)
I was an American Cancer Society Post-Doctoral fellow in the laboratory of Dr. Robert Haselkorn, Department of Molecular Genetics and Cell Biology.
Wrote software that aids finding bacterial open reading frames based on codon usage
Characterized heterocyst differentiation mutants of Anabaena sp. PCC 7120
non-degree , Statistics , 2001 — 2006
I have been taking courses to improve my skills in statistics and computer programming:
CAS MA 225 Multivariate Calculus
MET MA 242 Linear Algebra
MET MA 581 Probability (a calculus-based theory course)
MET MA 582 Mathematical Statistics (a calculus-based theory course)
CAS MA 416 Intermediate Statistical Methods (an applied course, using SAS)
MET CS 231 Introduction to Computer Science for Programmers with C++
CAS MA 684 Multivariate Analysis (an applied course, using SAS)
Ph.D. , Molecular Biology , August 1983 — May 1989
B.A. , Biology , September 1979 — June 1982
B.A. , Chemistry , September 1974 — June 1979
Physics, astronomy September 1972 — June 1974