Chris de Graaf

Current

• Assistant professor at VU University Amsterdam

Past

• postdoctoral fellowship at Université Louis Pasteur Strasbourg/AstraZeneca
• PhD student at Vrije Universiteit Amsterdam

Education

• Vrije Universiteit Amsterdam
• Universiteit van Amsterdam

Connections

204 connections

Industry

Pharmaceuticals

Chris de Graaf’s Summary

Assistant Professor Computational Medicinal Chemistry with Vrije Universiteit Amsterdam (from 2008)

Awarded Veni grant by Dutch Organisation for Scientific Research (NWO) (2009)

Postdoctoral Fellow with ULP Strasbourg/AstraZeneca (2006-2008)

PhD (with honors) in Computational Medicinal Chemistry and Toxicology from Vrije Universiteit Amsterdam (2006).

MSc (with honors) in Chemistry from Universiteit van Amsterdam (2002).

Almost 9 years of experience in molecular modeling and structure-based design techniques and their application to pharmaceutically relevant protein systems, like GPCRs and cytochrome P450 enzymes.

Almost 3 years experience in the research environment of a pharmaceutical company (AstraZeneca) and contributed to various drug development projects.

Used to working in multidisciplinary research projects and closely collaborate with experimental scientists.

> 20 scientific publications

Chris de Graaf’s Specialties:

computer-aided drug design, protein modeling (specifically GPCRs and CYPs), molecular dynamics simulations, free energy calculations, automated docking, protein-based and ligand-based virtual-screening, bioinformatics, chemoinformatics, interpretation SAR and SDM data, in silico methods to guide and support experimental studies (spectroscopy, enzymology, biopharmacology, medicinal chemistry)

Chris de Graaf’s Experience

• Assistant professor

  VU University Amsterdam

  (Pharmaceuticals industry)

  2008 — Present (1 year )

• postdoctoral fellowship

  Université Louis Pasteur Strasbourg/AstraZeneca

  (Pharmaceuticals industry)

  February 2006 — November 2008 (2 years 10 months)

  Development and application new GPCR modeling and virtual screening techniques

• PhD student

  Vrije Universiteit Amsterdam

  (Educational Institution; 1001-5000 employees; Research industry)

  January 2002 — January 2006 (4 years 1 month)

  Cytochrome P450-drug interactions: Computational binding mode and affinity predictions in CYP2D6

Chris de Graaf’s Education

• Vrije Universiteit Amsterdam

  PhD , Pharmaceutical Sciences/Computational Chemistry , 2002 — 2006

  Cytochrome P450-Drug Interactions: Computational binding mode and affinity predictions in CYP2D6
  Homology modeling, molecular dynamics, free energy calculations, automated docking, virtual screening, guiding and rationalizing experimental studies (site-directed mutagenesis, NMR, fluorescence and Raman spectroscopic studies)
  Publishable results, teaching bachelor and master students

• Universiteit van Amsterdam

  MSc , Environmental Chemistry/Computational Chemistry , 1997 — 2002

  Biodegradation of azaarenes (microbiology, analytical chemistry, biochemistry)
  Fate modeling of nonylphenol ethoxylates (environmental chemistry, fate modeling/risk assessment)
  Publishable results