Adrian Heilbut

statistics, cs, and biology

Location
Cambridge, Massachusetts (Greater Boston Area)
Industry
Computer Software

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Adrian Heilbut's Overview

Current
Past
  • Associate Scientist, Computational Biology at CombinatoRx Inc
  • Research Associate at University of Toronto, Department of Biochemistry
  • Bioinformatics at MDS Proteomics
Education
Connections

259 connections

Adrian Heilbut's Education

Boston University

MS, Bioinformatics

20082010

University of Toronto

B.Sc.(Hon), Computer Science, Neuroscience

19962001

Activities and Societies: University College Literary & Athletic Society, Hart House Chorus

UCC

Grade 4 - OAC, Bremner's

19871996

Adrian Heilbut's Experience

PhD candidate

Broad Institute

Nonprofit; 501-1000 employees; Research industry

October 2011Present (3 years) Cambridge, MA

PhD candidate

Boston University

Educational Institution; 5001-10,000 employees; Higher Education industry

January 2008Present (6 years 9 months) Boston, MA

Founder

Nonstationary, Inc.

May 2008Present (6 years 5 months) Cambridge, MA and New York, NY

Data science consulting
Applied statistics, machine learning, and visualization
Python software development

Adjunct Instructor, Dept. of Mathematics & Statistics

Boston University

Educational Institution; 5001-10,000 employees; Higher Education industry

January 2014May 2014 (5 months)

Co-instructor for MA213, Introduction to Statistics
Responsible for computer laboratory and project component of introductory undergraduate statistics course.

Adjunct Instructor

Lesley University

Educational Institution; 501-1000 employees; Higher Education industry

January 2014May 2014 (5 months)

Taught CMATH2142, Introduction to Statistics

Bioinformatics Specialist

Massachusetts General Hospital

Nonprofit; 10,001+ employees; Hospital & Health Care industry

January 2010September 2011 (1 year 9 months)

Analysis of Illumina sequencing data to characterize genomic structural variation in patients with neurodevelopmental disorders.

Wrote tools in C++ (https://github.com/aheilbut/gattools) and python and contributed to analysis on three papers:

Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries.
Talkowski ME, Rosenfeld JA, Blumenthal I, Pillalamarri V, Chiang C, Heilbut A, Ernst C, Hanscom C, Rossin E, Lindgren AM, Pereira S, Ruderfer D, Kirby A, Ripke S, Harris DJ, Lee JH, Ha K, Kim HG, Solomon BD, Gropman AL, Lucente D, Sims K, Ohsumi TK, Borowsky ML, Loranger S, Quade B, Lage K, Miles J, Wu BL, Shen Y, Neale B, Shaffer LG, Daly MJ, Morton CC, Gusella JF.
Cell. 2012 Apr 27

Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration.
Chiang C, Jacobsen JC, Ernst C, Hanscom C, Heilbut A, Blumenthal I, Mills RE, Kirby A, Lindgren AM, Rudiger SR, McLaughlan CJ, Bawden CS, Reid SJ, Faull RL, Snell RG, Hall IM, Shen Y, Ohsumi TK, Borowsky ML, Daly MJ, Lee C, Morton CC, MacDonald ME, Gusella JF, Talkowski ME. Nat Genet. 2012 Mar 4;44(4):390-7

Next-generation sequencing strategies enable routine detection of balanced chromosome rearrangements for clinical diagnostics and genetic research.
Talkowski ME, Ernst C, Heilbut A, Chiang C, Hanscom C, Lindgren A, Kirby A, Liu S, Muddukrishna B, Ohsumi TK, Shen Y, Borowsky M, Daly MJ, Morton CC, Gusella JF.
Am J Hum Genet. 2011 Apr 8;88(4):469-81

Associate Scientist, Computational Biology

CombinatoRx Inc

Public Company; 51-200 employees; CRXX; Biotechnology industry

January 2005January 2008 (3 years 1 month) Cambridge, MA

Helped to plan and execute a 200x200 screen of small-molecule probes in oncology, aimed at identifying selective modulators of DNA damage signaling and apoptosis.

Maintained and extended automated platform for high-throughput cell-based screening of small molecule combinations.
- Developed and maintained software for control of liquid-handling robots
- Modification and troubleshooting of custom laboratory information managment systems (Java, SQL)

Contributed to multiple therapeutic discovery projects in inflammation, oncology, and infectious disease

Synergistic drug combinations tend to improve therapeutically relevant selectivity.
Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA.
Nat Biotechnol. 2009

Educational Institution; 10,001+ employees; Higher Education industry

September 2002December 2004 (2 years 4 months) Toronto, Canada Area

Development of software for modelling biochemical reaction system dynamics.
Molecular biology

Bioinformatics

MDS Proteomics

September 2000September 2002 (2 years 1 month) Toronto, Canada Area

Designed and developed laboratory information management system for biochemistry and protein mass spectrometry platform designed for high-throughput identification of protein complexes.

Developed web-based system ('piranha') for filtering and prioritization of mass spec results

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, Vo M, Taggart J, Goudreault M, Muskat B, Alfarano C, Dewar D, Lin Z, Michalickova K, Willems AR, Sassi H, Nielsen PA, Rasmussen KJ, Andersen JR, Johansen LE, Hansen LH, Jespersen H, Podtelejnikov A, Nielsen E, Crawford J, Poulsen V, Sørensen BD, Matthiesen J, Hendrickson RC, Gleeson F, Pawson T, Moran MF, Durocher D, Mann M, Hogue CW, Figeys D, Tyers M.
Nature. 2002 Jan 10

Adrian Heilbut's Skills & Expertise

  1. Bioinformatics
  2. Human Genetics
  3. Python
  4. Drug Discovery
  5. CherryPy
  6. R
  7. Statistics
  8. Experimental Design
  9. Bayesian statistics
  10. Data Science
  11. C++
  12. SQL
  13. pandas
  14. NumPy
  15. d3.js
  16. Scientific Data Management
  17. Databases
  18. Neuroscience
  19. Biochemistry
  20. Genomics
  21. Genome Sequencing
  22. High Throughput Screening
  23. Molecular Biology
  24. Machine Learning
  25. Computational Biology
  26. Proteomics
  27. DNA sequencing
  28. Sequencing

View All (28) Skills View Fewer Skills

Adrian Heilbut's Languages

  • English

    (Native or bilingual proficiency)
  • French

    (Elementary proficiency)

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