GlaxoSmithKline plc, together with its subsidiaries, engages in the creation, discovery, development, manufacture, and marketing of pharmaceutical and consumer health-related products. Its Pharmaceuticals segment manufactures prescription drugs and vaccines that are used in various therapeutic areas, including central nervous system, respiratory, anti-viral, anti-bacterial, oncology and emesis, metabolic, cardiovascular, and urogenital. This segment offers Seretide/Advair for asthma and chronic obstructive pulmonary disease (COPD); Avandia for the treatment of type 2 diabetes; Lamictal for epilepsy and bipolar disorder; Wellbutrin, an anti-depressant; Zofran to prevent nausea and vomiting associated with chemotherapy and radiotherapy for cancer; Valtrex for herpes; Coreg for heart disease; and Imigran/Imitrex for migraine and cluster headache. Its products also include Augmentin for the treatment of bacterial infections; Seroxat/Paxil for the treatment of depressive disorder, panic, obsessive compulsive disorder, post traumatic stress disorder, social anxiety disorder, and generalized anxiety disorder; and Flixotide/Flovent, an inhaled steroid for the treatment of inflammation associated with asthma and COPD. The company’s Consumer Healthcare segment offers over-the-counter medicines, oral care, and nutritional healthcare products. Its products comprise Lucozade energy and sports drinks; Aquafresh and Sensodyne toothpastes and mouthwashes; Aquafresh and Dr Best toothbrushes; Panadol, a paracetamol/acetaminophen analgesic; Horlicks, a milk-based malted food and chocolate drinks; and Ribena, a blackcurrant juice-based drink. GlaxoSmithKline operates in the United States, Europe, Japan, the Asia Pacific, the Middle East, Latin America, Africa, and Canada. It has agreements with Anacor Pharmaceuticals, Inc.; Oncomed Pharmaceuticals, Inc.; Santaris Pharma A/S; and Targacept, Inc. The company was founded in 1935 and is headquartered in Brentford, the United Kingdom.