Masthead Venture Partners is a venture capital firm specializing in investments in all stages of company growth with a focus on seed to early and emerging growth. The firm prefers to invest in information technology and life science companies with a focus on software and enterprise applications, Internet infrastructure, communications technology, wireless technology and applications, information technology intensive life science applications, and medical technology. It seeks to invest in companies based in the Northeastern United States. The firm typically invests between $1 million and $8 million in the first institutional round. It makes an overall investment of $5 million to $8 million in each portfolio company, including later rounds. The firm prefers to act as lead investor however it can lead or co-lead the first and second round funding in syndication with other investors. Masthead Venture Partners is based in Cambridge, Massachusetts with an additional office in New York City.